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The GENcast NETWORK ALERT


Peixuan Guo


John Sterling

PODCAST: "Nanotechnologists Create Artificial Pore"

—Peixuan Guo, Ph.D., Director of the NIH Nanomedicine Development Center at the University of Cincinnati, Endowed Chair, and Professor of Biomedical Engineering, is interviewed by John Sterling, Editor in Chief, Genetic Engineering & Biotechnology News.
 

WHEN: November 6 – November 20, 2009

Using an RNA-powered nanomotor, University of Cincinnati (UC) biomedical engineering scientists successfully developed an artificial pore able to transmit nanoscale material through a membrane.

In a study led by Dr. Peixuan Guo, members of the UC team inserted the modified core of a nanomotor into a lipid membrane. The resulting channel enabled them to move both single- and double-stranded DNA through the membrane.

During this week’s podcast Dr. Guo talks about the creation of the RNA nanomotor and provides additional details on how it was used and on the results that were obtained. He discusses the key differences between the UC team’s single pore construct and other systems and explains the importance of such differences.

Dr. Guo goes on to explore the potential use of the engineered biopore channel and looks at some of the broader applications of the method by which the scientists were able to move DNA through the membrane.

LISTEN NOW to this week's GEN podcast.

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Genetic Engineering & Biotechnology News
Overcoming LC/MS Data Overload in Biotherapeutic Characterization
 

Genetic Engineering & Biotechnology News Presents an Informative and Educational Streaming Audio Webinar

Overcoming LC/MS Data Overload in Biotherapeutic Characterization

Click Here to Register

Broadcast Date: Wednesday, November 18, 2009
Time: 1:00 pm EST

The most significant challenge for efficient biotherapeutic protein characterization is not the acquisition of LC/MS peptide-mapping data but the analysis of these results. Through this webinar you will become familiar with the issues surrounding LC/MS peptide-mapping analysis and how the appropriate bioinformatics tools can make a huge difference in streamlining an analyst’s overall LC/MS workflow.

Who should attend
  • Scientists involved in the discovery and development of protein biotherapeutics
  • Analysts charged with biotherapeutic protein characterization studies
  • CRO/CMO and academic core facilities supporting biotechnology 
  • Researchers tasked with demonstrating the comparability of follow-on biotherapeutics

Key learning points

  • Introduction to processing of LC/MS peptide-mapping data and an overview of the complexity observed in such studies
  • Tools and workflows used for characterization of recombinant therapeutic proteins
  • Comparison of previous manual data-analysis approaches that were reduced from weeks to days by employing appropriate informatics. Specific examples will be given for the assessment of disulfide bonding patterns in recombinant proteins
  • A case study on managing peptide-mapping results using an archival database approach developed at Alexion. Use of this database eliminates the need to re-analyze peptides identified during previous analyses and focuses investigators on the task of analyzing new product variants that arise due to process changes and other factors 

Panelists include

Scott Berger, Ph.D., Market Development Manager, Biopharmaceutical Sciences Group, Waters; Yan Wang, Ph.D., Scientist I, Analytical Biochemistry, Protein Drug Discovery, Biogen Idec; and Adam Lucka, Scientist II, Alexion Pharmaceuticals.

Your host for this webinar will be John Sterling, Editor in Chief of Genetic Engineering & Biotechnology News. A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelists. For more information on this webinar, click here.

We look forward to your participation!

Reserve Your Complimentary Webinar Seat
 

Panelists

 
Yan Wang, Ph.D.
Scientist I
Biogen Idec
 
Adam W. Lucka,
Scientist II
Alexion Pharmaceuticals
 
Scott Berger, Ph.D.
Market Development Manager
Waters
MODERATOR
John Sterling
Editor in Chief
Genetic Engineering
& Biotechnology News

Produced with support from
Waters - www.waters.com
 

 

 
Agilent Technologies
We make it. You make it happen.
Next Generation Sequencing: Improved Library Quantification with Agilent Technologies
A Live eSeminar!

Accurate quantification of in process Next Generation sequencing samples is critical for reliable sequence data. The inclusion of a novel Agilent QPCR method and LabChip technology in typical NextGen workflows results in increased data quality with a more efficient use of reagents and starting DNA.

Presenter:
Scott D. Leppanen
Senior Field Application Scientist
Agilent Technologies

Date: Thursday, November 19, 2009
Time: 11:00 a.m. ET
Duration: 1 Hour

> Register here